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ea0021p270 | Pituitary | SFEBES2009

Hypothalamic resistance to signals of energy reserve, rather than excess appetite stimulation, may contribute to obesity in CP patients

Crowley Rachel K , Barrett Patricia , Woods Conor , Fleming Michelle , Behan Lucy Ann , O'Sullivan Eoin P , Rogers Bairbre , Agha Amar , Smith Diarmuid , Thompson Christopher J

Obesity is a recognised complication of craniopharyngioma (CP), but its aetiology is not understood. Leptin, which signals energy reserve, and ghrelin, which regulates appetite, are implicated in the development of obesity.Our aim was to assess leptin and ghrelin levels in CP patients and to compare these to normal and BMI-matched controls.CP patients were identified from the local database. All CP patients were on hormone replacem...

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Hypothalamic resistance to signals of energy reserve, rather than excess appetite stimulation, may contribute to obesity in CP patients

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